Likewise, in endometria from women with a high body mass index (BMI) and PCOS, insulin-mediated glucose uptake machinery is altered, characterized by a lower expression of GLUT4 insulin-dependent glucose transporters, phosphorylation of IRS1 and AS160 and protein levels of the WAVE family, which leads to a lower translocation of GLUT4 vesicles from the intracellular compartment to the cellular plasma membrane [4,6]. The gene discussed is IRS1; the disease is polycystic ovary syndrome.