NFKB1 and obesity due to melanocortin 4 receptor deficiency: Figure 3 shows that p-p38-MAPK levels were lower in endometria from women with obesity + IR and obesity + IR + PCOS after MTF treatment compared to all other groups (p < 0.05) (Figure 3A). Regarding NF-κB, the data show that MTF can lower the nuclear presence of NF-κB in endometrial tissue from women with obesity + IR and obesity + IR + PCOS compared with the control group or women without treatment (p < 0.05) (Figure 3B).