APPL2 and obesity due to melanocortin 4 receptor deficiency: In this investigation, it has been shown that MTF could improve insulin signaling by increasing the levels of molecules involved in insulin (p-AS160) signaling and regulating molecules involved in adiponectin signaling (APPL1, APPL2 and p-MEK) in endometrial cells under TNFα conditions intended to emulate the obesity condition.