On the other hand, all the evidence indicates that the action of insulin sensitizing molecules, either exogenous molecules, such as MTF (or myo-inositol as in other studies), or endogenous molecules, such as adiponectin, can improve insulin sensitivity in endometrial cells in pathological environments related to obesity-associated IR in the presence or absence of PCOS. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.