EZH2 and neoplasm: To determine the effect of dual inhibition of H3K9 and H3K27 methylation, tumor cell lines were treated with the G9a inhibitor, UNC0642 (1 μM), and the EZH2 inhibitor, UNC1999 (5 μM), or UNC0642 (1 μM) +UNC1999 (5 μM) for seven days (Figure S2).