TGFB1 and major depressive disorder: A network of these five pathways and 95 genes that showed a strong interaction with these 10 miRNAs is presented in Figure 2B. Figure 2C,D shows the genes interacting with these miRNAs in the TGF-β signaling pathway and long-term depressive pathway, respectively, which are strongly associated with these miRNAs and are also involved in depression.