An in vitro study using MT-infected human leukocytes showed that 1,25(OH)2D significantly attenuated MT-induced increases in expression of MMP-7 and MMP-10, and suppressed secretion of MMP-7 by MT-infected PBMC, whilst MMP-9 gene expression, secretion and activity were significantly inhibited by 1,25(OH)2D3 irrespective of infection [28,29]. This evidence concerns the gene MMP7 and infection.