The vitamin D receptor (VDR), after binding the activated vitamin D, forms a heterodimer with the retinoic acid receptor (RXR); then it is internalized in the cell and reaches the nucleus, where it interacts with the transcription factors and binds the gene portion of DNA responsive to vitamin D, called VDRE, thus influencing the expression or repression of genes, which include numerous metabolic and immune pathways and response regulation against cancer. This evidence concerns the gene VDR and cancer.