Lactadherin OE in advanced CRC tissues compared with early-stage CRC and adjacent non-cancerous tissues Lactadherin levels correlated with bad prognosis and survival parameters Lactadherin promotes CRC cell migration and invasion, increases levels of MMP-2 and MMP-9, and promotes EMT and promotes progression via AKT/MMPs signaling. This evidence concerns the gene AKT1 and colorectal carcinoma.