VWF and thrombotic thrombocytopenic purpura: As it is known from the pathogenesis of thrombotic thrombocytopenic purpura (TTP), the inhibited expression of ADAMTS-13 leads to the impairment of vWF cleavage, which, in turn, results in the development of disseminated platelet-rich thrombi in the circulation and the consequent activation of the inflammatory course [10].