ADAMTS13 and HELLP syndrome: The purpose of this state-of-the-art review is to present the most recent molecular advances in the pathogenesis of PE/HELLP syndromes, recent scientific data regarding the increased von Willebrand factor (vWF) antigen levels (vWF:Ag) in patients with PE, ADAMTS-13, and the dysregulation of the complement system will be highlighted and analyzed.