Further, it has recently been demonstrated that NPY delays the cellular aging phenotype associated to Hutchinson-Gilford Progeria Syndrome (HGPS), paving the way for the hypothesis that this neuropeptide may be exploited to block the premature onset of aging hallmarks in patients affected by HGPS by stimulating autophagy and decreasing progerin accumulation, rescuing nuclear abnormalities, and delaying cellular senescence [39]. This evidence concerns the gene NPY and Hutchinson-Gilford progeria syndrome.