Genotyping of 578 HNSCC patients and 588 cancer-free controls for 60 EGFR SNPs revealed intronic SNPs rs12535536, rs2075110, rs1253871, rs845561, and rs6970262, and synonymous SNP rs2072454 were associated with HNSCC risk among all HNSCC patients [81]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.