Breast cancer MCF7 and PRODH/POX CRISPR/Cas9 knockout MCF7 cells (MCF7POX-KO) were treated with 0.5 mM indomethacin and 0.375 mM diclofenac for 24 h to recognize the role of PRODH/POX in NSAID-dependent apoptosis. This evidence concerns the gene PRODH and breast carcinoma.