Furthermore, 11 of the genes (ADA, CPNE8, C14orf126, ERGIC2, HMGA2, PLS3, PSMD10, RALB, SERPINE1, SFXN1, and TMEM87B) predicted a significantly poorer prognosis in HNSCC patients (Figure 3 and Figure 4). Here, PLS3 is linked to head and neck squamous cell carcinoma.