RHOA and cancer: A large number of studies showed that aberrantly expressed PSMD10/Gankyrin was present in several types of cancers, and its overexpression enhanced cancer cell proliferation, invasion, and metastasis through the activation of several oncogenic signal pathways, e.g., RhoA/ROCK/PTEN, PI3K/AKT, and IL-6/STAT3 pathways [42].