Among these targets, the high expression of 11 genes (ADA, CPNE8, C14orf126, ERGIC2, HMGA2, PLS3, PSMD10, RALB, SERPINE1, SFXN1, and TMEM87B) significantly predicted the short survival of HNSCC patients according to The Cancer Genome Atlas (TCGA) (5-year overall survival rate; p < 0.05). This evidence concerns the gene PLS3 and head and neck squamous cell carcinoma.