Several researchers have demonstrated that as a versatile regulator of cell differentiation, NFIB up-regulated its expression in gastric cancer [50], small-cell lung cancer [51], melanoma [52], and breast cancer [53], whereas paradoxically NFIB exhibits tumor suppressive functions in cutaneous squamous cell carcinoma and glioblastoma [54,55]. The gene discussed is NFIB; the disease is cutaneous squamous cell carcinoma.