IGHE and asthma: Der m 1, Der m 2, and the combination indeed caused mice asthma, and the increased allergen-specific-IgE and -IgG1 values represent the results of the Th2 response (Figure 4), and although the amounts of IgE and IgG1 in the Der m 1 + Der m 2-sensitized mice seem to have not significantly increased, its neutrophils are obviously higher (Figure 5).