APRT, ATP1B1, C3, CAV1, FH, ITGB1, LGMN, MAN2A1, PEX11A, and SLC22A6 were indicated as markers of renal fibrosis and HNMT, Cyp4a14, ACSM3 were in the panel of biomarkers for reversible glomerulonephritis in rat. The gene discussed is SLC22A6; the disease is glomerulonephritis.