Endocytosis and vesicle mediated transport, protein localization, actin cytoskeleton organization, regulation of cell shape, cytoskeletal regulation by Rho GTPase, and integrin signaling are strongly enriched among the increased proteins in the HF group, as well as many proteins involved in lipid metabolism, thermogenesis, mitochondrial energetic metabolism, and PPAR (peroxisome proliferator-activated receptor) signaling (Supplementary Files S4 and S5, Figure 4A Increased). The gene discussed is PPARA; the disease is hydrops fetalis.