Conversely, the top five pathways of the 109 downregulated genes were pathways in cancer (6.6%), phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway (6.2%), mitogen-activated protein kinase (MAPK) signaling pathway (4.8%), Hippo signaling pathway (4.0%), and proteoglycans in cancer (4.0%) (Figure 5). This evidence concerns the gene AKT1 and cancer.