BCL2 and acute lymphoblastic leukemia: Interestingly, anti-apoptotic proteins are basally overexpressed in ALL, whereas pro-apoptotic members of the Bcl-2 family (for instance, Bax) are shown to be downregulated, pushing the balance between pro and anti-apoptotic factors towards the cell’s survival, which significantly contributes to treatment resistance [36,37,38,39,40,41,42,43].