Furthermore, NET stimulation of the resting macrophages induced the secretion of IL-8, IL-6, and TNFα [93], all proinflammatory cytokines that have been characterized to be dysregulated in RA and other autoimmune conditions [174,175,176,177], where antibodies targeting the latter two cytokines are currently used in the clinic for the treatment of RA [177,178]. This evidence concerns the gene TNF and rheumatoid arthritis.