IL1B and metabolic dysfunction-associated steatohepatitis: Amongst others, the depletion of macrophages in a high-fat diet-induced murine NASH model results in the decrease of inflammatory cytokines, such as IL-1β, IL-15, complement component C1, and Ccl6, whereas the fatty oxidation gene peroxisome proliferator-activated receptor alpha (PPARα) was increased, resulting in a decrease of liver triglyceride and glucosylceramide.