KLF2 and Hepatic fibrosis: Under physiological conditions, fenestrated LSECs promote liver stem cell quiescence, whereas capillarized LSECs initiate stem cell activation through the release of PDGF (Table 1), and decreased expression of vasoprotective Kruppel-like factor 2 (KLF2), preceding liver fibrosis, whereas in a normal state, fenestrated LSECs keep liver stem cells in quiescence [40].