After analyzing the interaction between 36 angio-miRNAs and the melatonin-modulated hypoxia-inducible factor-1 (HIF1)/VEGF/MMP9 axis, researchers found that miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, and miR-200b-3p may play important roles in malignant glioblastoma multiforme (GBM) tumorigenesis and invasion and that all of these miRNAs respond to melatonin therapy [48]. The gene discussed is MMP9; the disease is glioblastoma.