Various studies reveal that pancreatic carcinoma may feature multiple alterations of disease-related genes, including mutations and deletions of tumor-suppressant genes (such as p53, DPC4, p16, etc.), [50,51,52,53], as well as mutations and the overexpression of various oncogenes (such as K-ras, Her-2/neu) [54,55], which may extend to mismatch repair gene defects [56]. Here, SMAD4 is linked to neoplasm.