CASP8 and breast cancer: In MDA-MB-453 breast cancer cells, apigenin activates caspase-8, -9, and -3 and causes the cleavage of poly(ADP-ribose) polymerase (PARP), which results in apoptosis [82,83], and apoptosis is also induced by apigenin-mediated caspase-3 activation in MDA-MB-231, BT-474, SKBR3, T47D, and HBL-100 breast cancer cells [71,72,73,74,75,76,77,80].