CASP3 and skin neoplasm: Furthermore, apigenin with poly(lactide-co-glycolide)-containing nanoparticles was reported to improve the regulation of cell death and cytochrome c release and the expression of Apaf-1, Bax, Bcl-2, caspase-9, caspase-3, and PARP cleavage in A375 cells [101], and apigenin nanoparticles have been reported to contribute to the inhibition of ultraviolet (UV)-B-induced skin tumor growth by inducing caspase-3-mediated apoptosis [154].