Cortical protein aggregations of RBPs, such as heterogeneous nuclear ribonucleoproteins A0 and A1 (hnRNPA0 and hnRNPA1, respectively), heterogeneous nuclear ribonucleoprotein P2 (FUS), and TAR DNA-binding protein 43 (TDP-43), were found in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (tMCAO) [20]. The gene discussed is TARDBP; the disease is brain ischemia.