WWOX and cancer: Next, to consider a contribution of the Brca1-BRCT repeats to Wwox binding, we performed co-IP experiments, using MEFs expressing a cancer-associated missense variant M1717R (Brca1M1717R/M1717R, equivalent to human Brca1 M1775R) located in the BRCT domain, that disrupts Brca1-BRCT complex formation with pAbraxas, pBrip1, and pCtIP [28,34].