The tandem repeat BRCT domain (tBRCT) directly interacts with at least three phosphorylated proteins, Abraxas, Brip1 (aka Bach1/FANCJ), and CtIP (hereafter referred to as Abraxas, Brip1, CtIP), to form the A, B, C complexes, which are implicated with Brca1, in cell cycle regulation, specific DNA repair functions and tumor suppression [20,21,22,23,24,25,26,27]. The gene discussed is BRIP1; the disease is neoplasm.