According to their data, left ventricular dilatation was significantly higher, while ejection fraction was significantly lower in PACAP-deficent mice; moreover, the mortality rate was significantly higher, suggesting that endogenous PACAP plays an important role in cardiomyocyte protection, and indicating that a lack of PACAP indicates worse progression of HF [18]. The gene discussed is ADCYAP1; the disease is Left ventricular dilatation.