SERPINE1 and metabolic syndrome: ALL survivors with two or more MetS risk factors compared to the control group presented higher levels of C-peptide (p = 0.008), glucagon (p < 0.001), insulin (p = 0.020), leptin (p < 0.001), PAI-1 (p = 0.001), and a lower level of ghrelin (p = 0.001) (Table 4).