Since parkin-mediated K63-linked ubiquitination of synphilin-1 and alpha-synuclein results in the formation of Lewy body-like inclusions [188], it has been suggested that the formation of inclusions typical of PD and other conformational diseases is enhanced under the conditions promoting cellular K63-linked polyubiquitination [85]. The gene discussed is SNCA; the disease is Parkinson disease.