PDE6D and pancreatic ductal adenocarcinoma: Recent studies found that Deltarasin (Table 2) downregulates the RAS/RAF signaling pathway by inhibiting Phosphodiesterase-δ (PDEδ) binding with the hydrophobic pocket of PDEδ, resulting in the inhibition of KRAS-harbored pancreatic ductal adenocarcinoma (PDAC) [124,125].