Ubiquitin-conjugating enzyme E2C (UBE2C) was highly expressed in PCa compared with normal tissue in TCGA; the expression was also more highly associated with the Gleason score (>7) of PCa, which plays as an independent prognostic factor of PCa, and recreated a critical role in the pathway of PCa (WNT-β-catenin signaling pathway and NOTCH signaling pathway) [84]. This evidence concerns the gene UBE2C and posterior cortical atrophy.