MLLT3 and acute myeloid leukemia: Similarly, while Wei and colleagues demonstrated the exclusive generation of AML by transducing human UCB CD34+ HSPCs with the KMT2A/MLLT3 fusion gene prior to transplantation into NS-SGM3 [212], Horton et al. [213] showed that human UCB CD34+ HSPCs transduced with the KMT2A/MLLT3 fusion gene generated both AML and ALL in NSG mice, whereas similarly transduced adult bone marrow HSPCs generated LT hematopoietic engraftment with a myeloid bias, which did not progress to AML.