In the following study, we test if NTF2 is capable of trans-reducing NOTCH3 and compare the reductive features of NTF2 to those of NTF; further, we explore the possibility that the NOTCH3-derived protein liberated by cleavage at Asp121 can interact with NOTCH3 in brain tissue from SVD patients. The gene discussed is NOTCH3; the disease is snowflake vitreoretinal degeneration.