Of note, the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) has been shown to be essential to the anti-inflammatory roles of CO released from CORM-2 in LPS-induced endotoxemia, as the deletion of Nrf2 significantly abolished the beneficial effects of CO [130]. The gene discussed is NFE2L2; the disease is serum lipopolysaccharide activity.