IL13RA1 and familial pancreatic carcinoma: IL-4 and IL-13 act on pancreatic cancer cells mainly through their receptor heterodimers IL-4-receptor-alpha (IL-4Rα) and IL-13Rα1, termed type II IL-4R, via signal pathways of STAT3/6, IRS-ERK/PI3K-Akt and mTOR [23].