Firstly, it should also be noted that human SLC13A5/INDY has a much lower affinity for citrate than its mouse counterpart [107,108] and loss of function mutations of SLC13A5/INDY in humans leads to severe disease such as early infantile epileptic encephalopathy-25/developmental epileptic encephalopathy-25 [109,110] reviewed in [107,108]. This evidence concerns the gene SLC13A5 and early-infantile DEE.