In T2DM and T2DM mouse models, dapagliflozin reduced mesangial expansion, macrophage infiltration, and interstitial fibrosis, through significant attenuation of STAT1 and TGFβ1 expression, both factors associated with tubulointerstitial fibrosis in DKD [119,311]. This evidence concerns the gene STAT1 and type 2 diabetes mellitus.