Functional pathway analysis of the 2 dysregulated miRNA identified several signaling pathways including pathways in cancer, signaling pathway regulating pluripotency of stem cells, and mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK) signaling pathway in the vitreous of high myopic MH eyes. This evidence concerns the gene WNK2 and cancer.