The animal model is described in detail in the Materials and Methods section, and the treatment regimen in our in vivo experiment is shown in Figure 3A. As previously described, our K14-CreERtam/LSL-K-rasG12D/+ mice developed severe squamous cell papilloma in the oral mucosa within 1 month after tamoxifen treatment [22]. Here, KRT14 is linked to squamous papilloma.