AngII, the main effector peptide of the renin-angiotensin system, is a pro-inflammatory octapeptide that has been implicated in multiple aspects of cancer progression such as proliferation, migration, invasion, angiogenesis, and metastasis, with an increasing number of studies showing a relationship between ACE/AT1/AngII dysregulation and carcinogenesis [4,25]. This evidence concerns the gene REN and cancer.