In lung, another current subject in search for treatment options, increased TRPC6 responses of smooth muscle and vascular endothelial cells are associated with acute hypoxic vasoconstriction [13] but also with idiopathic pulmonary arterial hypertension (IPAH) [14] and lung ischemia-reperfusion edema (LIRE) [15,16]. This evidence concerns the gene TRPC6 and idiopathic pulmonary arterial hypertension.