TRPC6 and Hypertension: In particular, high expression of TRPC6 is observed in kidney, and mutations in the TRPC6-encoding gene are associated with progressive glomerular diseases like primary or secondary focal segmental glomerulosclerosis (FSGS), glomerulosclerosis as consequence of autoimmune glomerulonephritis or associated with diabetes mellitus type-1 or hypertension [11,12].