Among them, TRIM33/TIF-1γ has been reported to act as a SUMO E3 ligase of the transcriptional regulator, SnoN1, regulating the epithelial–mesenchymal transition (EMT) in organoids that derived from human breast cancer cell lines MDA-MB-231 and MCF7, and murine mammary gland epithelia cells [128]. This evidence concerns the gene TRIM33 and breast carcinoma.