Upon DNA damage, Pc2/CBX4 can mediate the SUMOylation of hnRNP K to enhance the transcriptional activity of p53 [160], except for RanBP2 and TRIM25, which, combined with androgen-induced G3BP2, increased the SUMOylation of p53, promoting its nuclear export, which facilitated the cellular proliferation and suppressed apoptosis in prostate cancer [161,162]. This evidence concerns the gene CBX4 and Familial prostate cancer.