Other genes here identified were the subject of previous studies: Rogge et al. [60] demonstrated the potential therapeutic efficacy of soluble Fas ligand (FASLG), which decreased inflammation and angiogenesis in primary and recurrent forms of herpetic stromal keratitis in a mouse model; a study based on a proteomic approach aimed at identifying putative biomarkers in tears from patients affected by DED secondary to rheumatoid arthritis highlighted reduced expression of SHC transforming isoform 1 (SHC1) in 63% of cases [61]. Here, SHC1 is linked to rheumatoid arthritis.