Some less common neurodegenerative diseases, mainly include a series of neurodegeneration with brain iron accumulation (NBIA), such as Friedreich’s ataxia (FRDA), Aceruloplasminemia, Neuroferritinopathy, and Pantothenate kinase-associated neurodegeneration (PKAN). This evidence concerns the gene PANK1 and neurodegeneration with brain iron accumulation.