Furthermore, Han et al. [40] described the accumulation of cytosolic dsDNA and cGAS-dependent cytokine production in IL-33-stimulated human bronchial cells and in mice submitted to three different allergic airway inflammation protocols, highlighting the important role of IL-33 induced cytosolic dsDNA accumulation and cGAS/STING pathway activation to asthma pathogenesis. The gene discussed is CGAS; the disease is asthma.