LPA and hyperlipoproteinemia: As an example, we have postulated some 40 years ago that patients with Type-II hyperlipoproteinemia (grossly elevated LDL-C) plus a serum Lp(a) concentration exceeding 30 mg/dL are at a >10-fold risk for myocardial infarction, in comparison to individuals with Lp(a) > 30 mg/dL and normal LDL-C.