Moutsopoulos et al. [14] could show that the overexpression of the proinflammatory cytokines IL-23 and IL-17 in LAD I-associated periodontitis and blocking of the p40 subunit of IL-23/IL-12 via ustekinumab led to a resolution of the inflammatory lesions and diminished IL-17 levels. The gene discussed is IL37; the disease is periodontitis.