CD274 and cervical cancer: M2 polarized macrophages are also abundant in the cervical cancer microenvironment, induced by IL-6 and prostaglandin E2 production by CC cells; in vitro studies show high levels of tumor promoting factors, such as PD-L1, VEGF and IL10 when colorectal EGFR+ cancer cells were exposed to IgG anti EGFR (cetuximab) in an environment rich in M2 polarized macrophages, therefore, impairing cetuximab antitumoral activity [72].