Using three different mouse lines with both complete loss (homozygous) and haploinsufficiency (heterozygous) of CIB2 in the retinal pigmented epithelium (RPE), Sethna et al. proved that abnormally low expression levels of CIB2 induced in mice age-related features similar to those found in dry AMD patients, which resulted in attenuated electroretinogram (ERG) amplitudes, indicative of visual loss. This evidence concerns the gene CIB2 and dry age related macular degeneration.