In a very recent work, Sethna et al. [15] reported a novel role for CIB2, which has deep implications for cell signaling and, in particular, for the mechanisms underlying the development of age-related macular degeneration (AMD), a multifactorial disorder of the macula, causing central vision loss, affecting 25% of people over 75 years old [57]. The gene discussed is CIB2; the disease is age-related macular degeneration.