Furthermore, Ji H. et al. [38] analyzed the secretome protein profiles released in vitro from isogenic human colorectal cancer (CRC) cells; the analysis resulted in observing the selective enrichment of the metastatic CRC cell exosomes with key metastatic factors (MET, S100A8, S100A9, TNC) and signal transduction molecules (EFNB2, EGFR, JAG1, SRC, TNIK) relative to primary CRC cell exosomes [38]. This evidence concerns the gene EFNB2 and colorectal carcinoma.