These sense viral infections and stimulate downstream transcription factors, including interferon (IFN)-regulatory factor 3 (IRF3), IRF7, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB, consisting of p65 and p50), and signal transducer and activator of transcription (STAT) proteins [106]. Here, NFKB1 is linked to viral infectious disease.