Furthermore, 5-aza-2′-deoxycytidine (5-aza-CdR) is a DNA methyltransferase inhibitor that reactivates silenced genes [30] and exhibits antitumor activity against anaplastic large cell lymphoma (ALCL) by inducing apoptosis and cell cycle arrest mediated by demethylation and activation of p16 following drug treatment [31]. Here, CDKN2A is linked to anaplastic large cell lymphoma.