In addition to its direct role in regulating CSCs and epithelial to mesenchymal transition (EMT), the Notch pathway cross-talks with several pathways including Ras, Wnt, nuclear factor kappa B (NF-κB), Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling and others, which contribute to cancer cell proliferation [21]. Here, NFKB1 is linked to cancer.