Cognitive impairment in transgenic AD models is also accompanied by accumulations of phosphorylated tau, which are composed of aberrant forms of phosphorylated tau [78,79,80]; indeed, higher activities of GSK3β and Cdk5 kinases result in accumulation of hyperphosphorylated tau in 12-month-old APPswe mice [81,82,83]. Here, MAPT is linked to Alzheimer disease.