APP and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is a neurodegenerative disorder among the elderly, characterized by progressive deterioration of cognition, with a complex etiology involving multiple processes [1] Neuropathological features include senile plaques (SP) composed of aggregated amyloid β peptides (Aβ) derived from aberrant processing of the amyloid precursor protein (APP), neurofibrillary tangles (NFT) composed of hyperphosphorylated tau protein, and synaptic and neuronal loss [2].