NLRP3 and metabolic dysfunction-associated steatohepatitis: Knocking-down Chop using siRNA inhibited the activity of caspase-11, caspase-1 and IL-1β, but not of active caspase-3, in tunicamycin or tunicamycin + LPS-induced primary hepatocytes; this indicates that ER stress induced NLRP3 inflammasome pyroptosis to cause injury of the LPS-induced NASH model via CHOP.